Apo diet e gene
Extensive research on APOE variants and dietary interactions has allowed us to better understand the dietary and lifestyle requirements for carriers of all genotypes (Table 3). Apolipoprotein E enhances proteolytic break-down of this peptide, both within and between cells. Low-fat diets can help reduce the risk for these diseases. APOE was initially recognized for its importance in lipoprotein metabolism and cardiovascular disease. This genotype is associated with a normal level of blood cholesterol. Genetic variations in the APOE gene predispose people to different levels of blood cholesterol in response to dietary fat. According to crystallography studies, a hinge region connects the N- and C-terminal regions of the protein. The gene, APOE, is mapped to chromosome 19 in a cluster with Apolipoprotein C1 and the Apolipoprotein C2. Apo E gene and genotype frequency in human population (adapted from Eichner et al, 2002. APOE transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. Apolipoproteins E at the US National Library of Medicine Medical Subject Headings (MeSH). Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store. Please use these recommendations wisely and factor in your personal health status and lifestyle. In general, E2 carriers are associated with low LDL cholesterol and low incidence of coronary heart disease. Not logged in Talk Contributions Create account Log in.
High blood cholesterol is a major risk factor for cardiovascular diseases. The differing risks for high blood cholesterol are the result of the enzymatic activity associated with the variants. Therefore, we can have two different APOE alleles. The distributions of E2, E3 and E4 are different in human populations. The APOE gene consists of four exons and three introns, totaling 3597 base pairs. Table 2: Determine your APOE status using SNPs rs429358 and rs7412. APOE4 is more common (20-30% occurrence) in Africans and Caucasians than in other ethnic groups. HealthWatch 360 - the best Gene Nutrition Health Tracker App. Human APOE genome location and APOE gene details page in the UCSC Genome Browser. The risks associated with these genotypes are gene dose-dependent. Table 1. The APOE gene makes the protein apolipoprotein E (Apo E) which is involved in the production, delivery, and utilization of cholesterol in the body. There are three common variants of the APOE gene: E2, E3, and E4. Since high fat diets often lead to high cholesterol, low-fat, high-carb diets are recommended for E4 carriers while high-fat, low-carb diets are recommended for E2 carriers. In contrast, the E4 variant makes a protein characterized by faster cholesterol metabolism resulting in a higher blood cholesterol level. The E2 variant makes a protein characterized by slower cholesterol metabolism, which results in a lower blood cholesterol.
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